In this episode, co-hosts Victoria Goldberg and Martha Carlso are joined by Josh Newby, Founder and Executive Director of Theresa’s Research Foundation (TRF), for an in-depth conversation about the evolving landscape of metastatic breast cancer research and advocacy. Josh shares the origins and mission of his foundation, the challenges faced in funding and organizing medical conferences, and the shift toward curative approaches for metastatic breast cancer. The discussion covers the impact of recent funding cuts, the importance of collaboration among institutions and industry partners, and the critical role of patient advocates. The group also explores the realities of grant funding, the effects of political and economic changes on research, and the need for credible information and community support for patients. Throughout, the conversation highlights the resilience and determination required to push forward in the face of uncertainty, emphasizing the message: we can’t turn back now.