Developing Story: Triple Negative MBC - Hard Truths, Real Hope with Dr Sarah Premji
Triple negative metastatic breast cancer has long been considered the hardest subtype to treat. That is changing and faster than most patients realize. Dr. Sarah Premji joins Victoria Goldberg to break down two landmark FDA approvals, the science behind antibody-drug conjugates, and what's coming next in the pipeline
Symptoms Spotlight: Bloood Clots with Abigail Johnston and Melanie Sisk
Blood clots are one of the most serious risks facing people with metastatic breast cancer, yet many patients don't learn about them until after a diagnosis has already happened. In this Symptom Spotlight, a registered nurse and an MBC patient sit down to talk through what you need to know, from understanding your personal risk factors to recognizing symptoms and knowing when to ask for help.
Developing Story: Your Cancer's DNA and the Trial Using It to Cure You with Dr. Pedram Razavi
What does it take to cure metastatic breast cancer? According to Dr. Pedram Razavi, it takes a blood test sensitive enough to find one cancer cell in a million, the courage to stop treatment when that signal disappears, and a trial designed to prove the paradigm wrong.
The HERizon-Breast Trial at Memorial Sloan Kettering is doing exactly that — and it's enrolling now.
This is one of the most science-rich episodes of Live from Stage 4 to date. We break down every term, every concept, and every implication in plain language so you don't need a medical degree to understand why this matters.
Symptoms Spotlight: Vaginal Dryness with Abigail Johnston and Melanie Sisk
"Nobody tells you about this part."
Vaginal dryness is one of the most common side effects of metastatic breast cancer treatment and one of the least talked about. In this episode, Abigail Johnston and Melanie speak candidly about what it is really like to navigate painful intimacy, shifting hormones, and the search for solutions while living with MBC
Developing Story: The Trial That Dares to Say Cure with Dr. Lior Braunstein
Dr. Lior Braunstein, radiation oncologist at Memorial Sloan Kettering, joins Victoria Goldberg and Ellen Landsberger to discuss the ARCHER trial — a groundbreaking study combining surgery and ablative radiation with standard HER2-targeted therapy in patients with oligometastatic HER2-positive breast cancer. The goal: eradicate every last cancer cell before resistance can emerge.
Developing Story: Beyond Camizestrant — The Evolving Landscape of ER+/HER2- MBC with Dr. Sarah Premji
The oral SERD era has arrived, and the treatment landscape for HR+/HER2- metastatic breast cancer is changing fast. Hosts Victoria Goldberg and Abigail Johnston sit down with Dr. Sarah Premji of Sarah Cannon to map out what has shifted beyond SERENA-6, from new FDA approvals and emerging mechanisms to real-world sequencing decisions and the latest trial data. If you are trying to make sense of a rapidly evolving algorithm, this episode is for you.
Symptoms Spotlight: Neutropenia with Abigail Johnston and Melanie Sisk
If you've ever gotten a blood draw before chemo and heard your nurse mention your ANC, this episode is for you. Neutropenia, a low white blood cell count, is one of the most common side effects of cancer treatment, and understanding it can make a real difference in how you advocate for yourself. Dr. Jill Tirabassi joins hosts Abigail Johnston and Melanie Sisk to break it all down, from what your numbers mean to what to do when they drop too low, and all three bring their own patient experiences to the table.
Developing Story: The Camizestrant Vote, Doctors Weigh In with Dr. Sarah Sammons & Dr. Neil Vasan
When the ODAC voted 6–3 against the camizestrant strategy, the headlines told you what happened — this episode tells you why. We're back for round two with Dr. Sarah Sammons, newly appointed Co-Leader of Breast Oncology at the University of Maryland Greenebaum Comprehensive Cancer Center, and Dr. Neil Vasan, Acting Chair of the ODAC and Director of Translational Research in Breast Cancer at NYU Langone Health, who sat in that room and cast one of the three yes votes. Alongside patient advocates Janice Cowden and Abigail Johnston, we break down the four FDA critiques that drove the vote, what the quality of life data showed and why regulators couldn't act on it, and what the FDA's new August 14th review deadline means for patients. Plus: why this science isn't going anywhere, and what ctDNA-guided treatment could look like in the very near future.
Symptom Spotlight: Melanie's Updates on Sleep Apnea and Constipation
Sometimes the symptoms you least expect turn out to be the most important ones to pay attention to. In this Symptom Spotlight update, Melanie shares two surprising diagnoses she received after recording our earlier episodes — obstructive sleep apnea and chronic constipation with diarrhea breakthrough — and how both were hiding in plain sight beneath what she assumed were normal cancer treatment side effects. If you're a metastatic cancer patient who's been brushing off fatigue, poor sleep, or digestive issues as "just part of treatment," this episode is for you.
Developing Story: The Camizestrant Vote — When Your Blood Test Knows Before Your Scan Does
Six MBC patient advocates join host Victoria Goldberg to break down the FDA advisory committee's vote on camizestrant and the SERENA-6 trial. The panel unpacks what the vote really means, whether the science of molecular progression is ready for clinical practice, and why patient advocates need a seat at the table before trials are designed.
Front Row Seat: Dr. Fatima Cardoso on Aiming Higher - Hope and the Road to a Cure
For decades, metastatic breast cancer meant one thing: managing the disease. But a new global report — and a bold new charter — say it's time to aim higher. Host Victoria Goldberg sits down with Dr. Fátima Cardoso of the ABC Global Alliance to examine 10 years of hard-won progress, confront the inequalities that have grown worse, and explore why, for the first time, the word cure is entering the conversation.
Symptoms Spotlight: Hair Loss with Abigail Johnston and Melanie Sisk
"Hair may seem like a small thing compared to staying alive. But hair is such an integral part of who we are — of how we see ourselves, and how the world sees us. It's important not to ignore the effect that losing our hair may have on our wellbeing." — Abigail Johnston
Stage 4 Living: Palliative Care is Not Hospice with Dr. Mary Busowski
Palliative care is not hospice — and that one misconception is keeping cancer patients from getting support they desperately need. Dr. Mary Busowski, palliative care physician at Orlando Health, joins our hosts Abigail Johnston and Amy Russell-Parliman o set the record straight and make the case for getting palliative care involved from day one.
S**t We Deal With Shorts: Time Burden with Dr. Jill Tirabassi
"You hear things like, 'living with cancer is a full-time job.' And actually this was an interesting study where we looked to see what truly is the time burden for people living with either metastatic breast or ovarian cancer... The time spent waiting and traveling for care often exceeded the amount of time receiving care. Most days, participants had a home cancer-related task to do—80% of days. The median was about 209 minutes per week doing cancer related tasks at home."
— Dr. Jill Tirabassi explores new research quantifying the invisible labor of living with metastatic cancer
Live Chat: The Courage to Choose Life on Your Terms with Dar Finkelstein
"One of my MBC friends said to me, 'You're feeling guilty about making people cry, but you've instilled in them so much joy and what they're doing, what you're seeing is them sharing the joy back to you.' And she said, 'It looks like tears, but that's their love coming back to you.'"
—Dar Finkelstein on accepting loved ones' grief
Podcasters Roundtable: Change Your One Thing with Gary Thompson
We don't have to change everything. We just have to change our one thing. And if we each indeed change our one thing, then we will have changed everything. My ideal audience is someone looking for their one thing and realizing that whatever it is, whenever they find it, to just follow their heart, follow their passion, and go for it. We as an individual person have the capacity to create great change. Love is neither big nor small. It's always enough
Symptoms Spotlight: Insomnia with Abigail Johnston and Melanie Sisk
One of the things a doctor said early on to me was to think about sleep as one of my medications. Part of my treatment plan was how much sleep I was getting. That's been something that I've tried to think about—that it's not just the thing that you do last, or it's not just the thing that you are irritated about and just get through, maybe drink some extra coffee and push through, which is kind of how I dealt with any times I had disruptions in sleep prior to cancer. But thinking about it as part of my treatment plan has helped me place the right importance on it
Symptoms Spotlight: Constipation with Abigail Johnston and Melanie Sisk
Hosts Melanie Sisk and Abigail Johnston have an honest conversation about constipation—a common but often unspoken side effect of cancer treatment. They discuss how to recognize constipation beyond the obvious symptoms, share practical remedies like MiraLax, Colace, and the "prune juice slider," and emphasize the importance of movement for digestive health. The duo also addresses the challenge of swinging between constipation and diarrhea, offering advice on when to troubleshoot on your own and when to seek help from your medical team or a GI specialist.
Our Happy Place: Heated Rivalry Rx
Victoria and Jill discuss their obsession with HBO Max's "Heated Rivalry," exploring why this hockey romance has become the perfect escape from MBC realities. Victoria shares personal insights as a Russian speaker, and the hosts draw parallels between sports teams and their community. Spoilers included!
Symptoms Spotlight: Diarrhea with Abigail Johnston and Melanie Sisk
Melanie Sisk and Abigail Johnston discuss managing diarrhea from cancer medications—a common but often embarrassing side effect. Learn practical strategies for treatment, when to seek specialist help, and how to advocate for better quality of life during cancer treatment.