Developing Story: CureWise Goes Live - The AI Platform Built by Cancer Patients, for Cancer Patients
You have ten minutes with your oncologist. Ten minutes to ask the right questions, understand what's happening inside your body, and make decisions that could change everything. For most cancer patients, that's not enough time — and nobody taught you how to prepare.
CureWise was built to change that. On June 20th, the AI platform created by cancer patients Steve Brown and Lisa Booth officially launched. On this episode of Live From Stage 4, we sit down with Steve, Lisa, and real beta users Lynda and Todd Weatherby to find out what it actually does, how it works, and why it matters.
Developing Story: Beyond Camizestrant — The Evolving Landscape of ER+/HER2- MBC with Dr. Sarah Premji
The oral SERD era has arrived, and the treatment landscape for HR+/HER2- metastatic breast cancer is changing fast. Hosts Victoria Goldberg and Abigail Johnston sit down with Dr. Sarah Premji of Sarah Cannon to map out what has shifted beyond SERENA-6, from new FDA approvals and emerging mechanisms to real-world sequencing decisions and the latest trial data. If you are trying to make sense of a rapidly evolving algorithm, this episode is for you.
Symptoms Spotlight: Neutropenia with Abigail Johnston and Melanie Sisk
If you've ever gotten a blood draw before chemo and heard your nurse mention your ANC, this episode is for you. Neutropenia, a low white blood cell count, is one of the most common side effects of cancer treatment, and understanding it can make a real difference in how you advocate for yourself. Dr. Jill Tirabassi joins hosts Abigail Johnston and Melanie Sisk to break it all down, from what your numbers mean to what to do when they drop too low, and all three bring their own patient experiences to the table.
Developing Story: The Camizestrant Vote, Doctors Weigh In with Dr. Sarah Sammons & Dr. Neil Vasan
When the ODAC voted 6–3 against the camizestrant strategy, the headlines told you what happened — this episode tells you why. We're back for round two with Dr. Sarah Sammons, newly appointed Co-Leader of Breast Oncology at the University of Maryland Greenebaum Comprehensive Cancer Center, and Dr. Neil Vasan, Acting Chair of the ODAC and Director of Translational Research in Breast Cancer at NYU Langone Health, who sat in that room and cast one of the three yes votes. Alongside patient advocates Janice Cowden and Abigail Johnston, we break down the four FDA critiques that drove the vote, what the quality of life data showed and why regulators couldn't act on it, and what the FDA's new August 14th review deadline means for patients. Plus: why this science isn't going anywhere, and what ctDNA-guided treatment could look like in the very near future.
Symptom Spotlight: Melanie's Updates on Sleep Apnea and Constipation
Sometimes the symptoms you least expect turn out to be the most important ones to pay attention to. In this Symptom Spotlight update, Melanie shares two surprising diagnoses she received after recording our earlier episodes — obstructive sleep apnea and chronic constipation with diarrhea breakthrough — and how both were hiding in plain sight beneath what she assumed were normal cancer treatment side effects. If you're a metastatic cancer patient who's been brushing off fatigue, poor sleep, or digestive issues as "just part of treatment," this episode is for you.
Developing Story: The Camizestrant Vote — When Your Blood Test Knows Before Your Scan Does
Six MBC patient advocates join host Victoria Goldberg to break down the FDA advisory committee's vote on camizestrant and the SERENA-6 trial. The panel unpacks what the vote really means, whether the science of molecular progression is ready for clinical practice, and why patient advocates need a seat at the table before trials are designed.
Thriving Together 2026: LBBC's MBC Conference Through Our Eyes
"You walk into a room full of people living with metastatic breast cancer and you just... break down. Not because it's sad — though it is — but because for the first time, you're not alone in it."
Twenty years in, LBBC's Thriving Together Conference is still doing what no other event in the MBC space does: bringing patients together not just to learn, but to find each other. In this episode, four MBC patients who attended the 2026 conference share what moved them, what the science is saying, and why they'll keep coming back.
Symptoms Spotlight: Hair Loss with Abigail Johnston and Melanie Sisk
"Hair may seem like a small thing compared to staying alive. But hair is such an integral part of who we are — of how we see ourselves, and how the world sees us. It's important not to ignore the effect that losing our hair may have on our wellbeing." — Abigail Johnston
Stage 4 Living: Palliative Care is Not Hospice with Dr. Mary Busowski
Palliative care is not hospice — and that one misconception is keeping cancer patients from getting support they desperately need. Dr. Mary Busowski, palliative care physician at Orlando Health, joins our hosts Abigail Johnston and Amy Russell-Parliman o set the record straight and make the case for getting palliative care involved from day one.
Front Row Seat: We'll Never Cure Cancer Without AI, Say Steve Brown & Lisa Booth
When Steve Brown's doctors missed his rare blood cancer for months, he turned to AI for answers. The system he built spotted the warning signs immediately—the same lab results his physicians had dismissed.
Now, as CEO of CureWise, Steve and patient advocate Lisa Booth are pioneering a new approach to cancer care: using AI agents trained as specialist doctors to help patients navigate treatment options, find clinical trials, and advocate effectively with their oncologists.
"There's a gap between what's possible and what most people are getting," Steve explains. "Cancer isn't just one disease. Everybody has their own unique version of it."
Lisa, an 11-year metastatic breast cancer survivor, adds: "My oncologist sees 600 patients. CureWise empowers me to show up to that seven-minute appointment with the right questions already researched and the clinical trials already identified."
This conversation explores how AI is transforming patient empowerment—and why knowledge might just save your life.
Live Chat: The Courage to Choose Life on Your Terms with Dar Finkelstein
"One of my MBC friends said to me, 'You're feeling guilty about making people cry, but you've instilled in them so much joy and what they're doing, what you're seeing is them sharing the joy back to you.' And she said, 'It looks like tears, but that's their love coming back to you.'"
—Dar Finkelstein on accepting loved ones' grief
Podcasters Roundtable: Change Your One Thing with Gary Thompson
We don't have to change everything. We just have to change our one thing. And if we each indeed change our one thing, then we will have changed everything. My ideal audience is someone looking for their one thing and realizing that whatever it is, whenever they find it, to just follow their heart, follow their passion, and go for it. We as an individual person have the capacity to create great change. Love is neither big nor small. It's always enough
Symptoms Spotlight: Insomnia with Abigail Johnston and Melanie Sisk
One of the things a doctor said early on to me was to think about sleep as one of my medications. Part of my treatment plan was how much sleep I was getting. That's been something that I've tried to think about—that it's not just the thing that you do last, or it's not just the thing that you are irritated about and just get through, maybe drink some extra coffee and push through, which is kind of how I dealt with any times I had disruptions in sleep prior to cancer. But thinking about it as part of my treatment plan has helped me place the right importance on it
Symptoms Spotlight: Constipation with Abigail Johnston and Melanie Sisk
Hosts Melanie Sisk and Abigail Johnston have an honest conversation about constipation—a common but often unspoken side effect of cancer treatment. They discuss how to recognize constipation beyond the obvious symptoms, share practical remedies like MiraLax, Colace, and the "prune juice slider," and emphasize the importance of movement for digestive health. The duo also addresses the challenge of swinging between constipation and diarrhea, offering advice on when to troubleshoot on your own and when to seek help from your medical team or a GI specialist.
Symptoms Spotlight: Diarrhea with Abigail Johnston and Melanie Sisk
Melanie Sisk and Abigail Johnston discuss managing diarrhea from cancer medications—a common but often embarrassing side effect. Learn practical strategies for treatment, when to seek specialist help, and how to advocate for better quality of life during cancer treatment.
Podcasters Roundtable: Melissa Berry on Fashion Meets Cancer Advocacy
Melissa Berry, founder of Cancer Fashionista and host of "Dear Cancer, I'm Beautiful," joins us to discuss building beauty and wellness resources for cancer patients. From her background as a fashion publicist to creating an evergreen podcast library, Melissa shares why looking like yourself matters, how she selects topics, and what keeps her connected to advocacy. We explore inclusive language for metastatic patients, financial toxicity, intimacy after cancer, and the power of podcasting as a tool for community building.
Symptoms Spotlight: Fatigue with Abigail Johnston and Melanie Sisk
Join hosts Melanie Sisk and Abigail Johnston as they shine a light on the real experiences of managing cancer symptoms. In each episode of the Symptoms Spotlight series of short episodes, we explore different symptoms caused by cancer or its treatment, sharing practical insights and hard-won wisdom directly from patients who've been there.
Melanie and Abigail share their experiences managing cancer-related fatigue over 5+ years of treatment. They discuss practical solutions including exercise programs like LiveStrong and Two Unstoppable, Medicare fitness benefits, medication options like Ritalin, and the importance of nutrition, hydration, and monitoring vitamin levels.
Fighting for Patients: Dr. Rebecca Shatsky on Insurance, Burnout, and Hope in MBC
Dr. Rebecca Shatsky, Director of Breast Medical Oncology at UC San Diego, shares her experiences fighting for patients with breast cancer. In this episode, Dr. Shatsky discusses the growing challenges clinicians face—from insurance denials and funding cuts to the emotional toll of burnout and the spread of cancer misinformation.
Hear real stories about advocating for life-saving treatments, navigating the complexities of clinical trials, and the importance of patient empowerment. Dr. Shatsky also offers hope, highlighting the latest breakthroughs in metastatic breast cancer research and the progress being made in treatment options.
Whether you’re a patient, caregiver, or healthcare professional, this episode delivers candid insights, practical advice, and a message of resilience and hope in the face of adversity.
Podcasters Roundtable: Samira Daswani, Host of The Patient from Hell
In this episode, hosts Victoria Goldberg and Abigail Johnston sit down with Samira Daswani, host of "The Patient From Hell" podcast, for a candid and insightful conversation about patient advocacy, storytelling, and the evolving landscape of cancer care. Samira shares her path from reluctant podcast guest to passionate host, highlighting the importance of amplifying patient voices and democratizing information for those navigating cancer diagnoses—especially in communities where open discussion is rare.
The discussion delves into the challenges of reaching diverse audiences, the power of authentic, minimally edited conversations, and the need for both scientific and personal perspectives in patient-centered content. The trio reflects on the shifting attitudes in cancer communities, the critical role of support networks, and the ongoing mission to educate and empower patients worldwide. The episode wraps up with ideas for future collaborations and a shared commitment to making a meaningful impact through storytelling and advocacy.
Future at Risk: Protecting Research, Protecting Lives
What if the decades of progress against cancer — the breakthroughs, the rising survival rates, the new vaccines and cutting‑edge therapies — were suddenly put in jeopardy? Five decades after the “war on cancer” began, the hard‑won momentum now faces existential threats: canceled grants and clinical trials, proposals to slash the NCI budget, and an unprecedented politicization of biomedical research funding.
Victoria Goldberg is joined by Pam Traxel, Senior Vice President at the American Cancer Society and a lifelong patient advocate.